Mutations Practice

Mutations Vocabulary Match each term to the correct description Insertion One or more nucleotides are added to a gene Frameshift mutation The addition or deletion of one or more nucleotides that changes the number of complete codons Point mutation A change in one nucleotide Deletion One or more nucleotides are removed from the gene Substitution One nucleotide is switched for another If the original DNA is ATAACGCCTATT, how many codons are there? 3 4 5 12 For the scenario above, when the "G" is deleted, how many complete codons would there then be? (Original - ATAACGCCTATT, "G" removed, New- ATAACCCTATT) 3 4 5 12 Using the following DNA sequence, determine the type of mutation that has occurred with the new sequence. Original: TAC ACC TTG GCG ACG ACT New sequence Type of mutation TAC ATC TTG GCG ACG ACT Substitution TAC GAC CTT GGC GAC GAC T Insertion TAC ACC TTG GGA CGA CT Deletion A geneticist found that a particular mutation had no effect on the protein coded by a gene. What do you think is the most likely type of mutation in this gene? Deletion Insertion Substitution Frameshift 1. Fill in the missing amino acids. ***Only type the first 3 letters of the amino acid. Ex. Methionine= Met******Type Stop for a stop codon***2. Fill in the mutated mRNA.***Capitalize the mRNA codons Ex. CUA***3. Fill in the mutated amino acids.***Only type the first 3 letters of the amino acid. Ex. Glutamic acid= Glu*** CUG GAA CCG CUG CUG Try Asp Arg Cys Stop Leu Glu Pro Leu Leu What type of mutation occurred in the question above? insertion deletion substitution Which of the following occurred in the question above? only 1 amino acid changed a frameshift mutation occurred a silent mutation occurred a premature stop was introduced Which type of mutation will have a bigger impact on a protein? (Which will affect more amino acids?) substitution insertion or deletion