Dna Mutations

What is the central dogma of molecular biology? DNA - RNA - Protein RNA - Protein - DNA DNA - Protein - RNA RNA - DNA - Protein What was the first type of mutation explained in the video? frameshift point nonsense silent What is the RNA strand of the mutated sequence used during the explanation of a point mutation? CTCCTCCTC GAGGAGGAG CTCCTCCAC GAGGAGGUG Where did the frameshift mutation occur? Between base 1 2 Between base 2 3 Between base 3 4 Between base 4 5 Between base 5 6 Between base 6 7 What type of mutation occurred during the first frameshift explanation? insertion deletion What type of gene mutation? Point usually only affects 1 amino acid Frameshift entire amino acid sequence can be changed insertion or deletion of a single gene or nucleotide base Sickle-cell disease is an example of what type of mutation? somatic frameshift point nonsense Using the video, fill in the blanks. Mutations originate at the DNA level, but show their effects at the protein level. Mutations can be classified by neither their effects on DNA or on protein. Identify each strand as either DNA or RNA DNA ATCGGCACAGCCGGTTT RNA AUGCAUGGGUAUACAA Use the codon chart to help on the next two sections. DNA mRNA Amino Acid AGG UCC Serine CGT GCA Alanine TCC AGG Arginine TTT AAA Lysine Use the following RNA sequence to determine if there is point or frameshift mutation. Original RNA:AUG CCC CGC UUA UAA Point AUG CGC CGC UUA UAA AUG GCC CGC UUA UAA AUG CCC CGC UUU UAA AUG CCC CGC UCA UAA Frameshift AUG CCC GCU UAU AA AUG CCC CCG CUU AUA A AUG CCC CGU UAU AA AUG CCC CGC UUA AUC UAA